PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure
نویسندگان
چکیده
منابع مشابه
Organophosphate Pesticide Exposure and Neurodevelopment in Young Mexican-American Children
BACKGROUND Organophosphate (OP) pesticides are widely used in agriculture and homes. Animal studies suggest that even moderate doses are neurodevelopmental toxicants, but there are few studies in humans. OBJECTIVES We investigated the relationship of prenatal and child OP urinary metabolite levels with children's neurodevelopment. METHODS Participating children were from a longitudinal birt...
متن کاملOrganophosphate Pesticide Exposure and Attention in Young Mexican-American Children: The CHAMACOS Study
BACKGROUND Exposure to organophosphate (OP) pesticides, well-known neurotoxicants, has been associated with neurobehavioral deficits in children. OBJECTIVES We investigated whether OP exposure, as measured by urinary dialkyl phosphate (DAP) metabolites in pregnant women and their children, was associated with attention-related outcomes among Mexican-American children living in an agricultural...
متن کاملPrenatal phthalate exposure and 8-isoprostane among Mexican-American children with high prevalence of obesity.
Oxidative stress has been linked to many obesity-related conditions among children including cardiovascular disease, diabetes mellitus and hypertension. Exposure to environmental chemicals such as phthalates, ubiquitously found in humans, may also generate reactive oxygen species and subsequent oxidative stress. We examined longitudinal changes of 8-isoprostane urinary concentrations, a validat...
متن کاملAssociation of Organophosphate Pesticide Exposure and Paraoxonase with Birth Outcome in Mexican-American Women
BACKGROUND Epidemiologic studies suggest that maternal organophosphorus (OP) pesticide exposure is associated with poorer fetal growth, but findings are inconsistent. We explored whether paraoxonase (PON1), a key enzyme involved in detoxification of OPs, could be an effect modifier in this association. METHODS The study population included 470 pregnant women enrolled in the CHAMACOS Study, a ...
متن کاملParaoxonase 1 (PON1), agricultural organophosphate exposure, and Parkinson disease
Background—Human, animal and cell models support a role for pesticides in the etiology of Parkinson disease. Susceptibility to pesticides may be modified by genetic variants of xenobiotic enzymes, such as paraoxonase, that play a role in metabolizing some organophosphates. Methods—We examined associations between Parkinson disease and the organophosphates diazinon, chlorpyrifos, and parathion, ...
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ژورنال
عنوان ژورنال: Environment International
سال: 2018
ISSN: 0160-4120
DOI: 10.1016/j.envint.2018.08.044